dengue serotype severity

In particular, Dengue-2 The major outcome assessed was symptomatic VCD of any severity caused by any dengue virus serotype. Leonel Perez. Results: A total of 771 dengue cases were studied, with 134 patients who developed severe dengue fever. Article Google Scholar 33. The most prominent factor which leads to severe dengue fever with complications is having a second or third infection with a different DENV serotype (Descloux et al., 2009; Ohainle et al., 2011; Guzman and Harris, 2015). Dengue virus serotypes 1 to 4 (DENV1 to -4) and Zika virus (ZIKV) are closely related mosquito-borne flaviviruses with high global burdens ( 1 , 2 ). It is also known as breakbone fever due to the severity of muscle spasms and joint pain, dandy fever, or seven-day fever because of the usual duration of symptoms. Accordingly, we sought to establish a mouse model to assess the impact … Schematic depiction of the symptoms of dengue fever. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 … Immunity will form when a person is infected with one type of serotype but does not apply when a secondary infection develops with another serotype; this can actually aggravate the disease until it … In 2008, dengue virus serotype 4 (DENV-4) emerged in northeastern Peru, causing a large outbreak and displacing DENV-3, which had predominated for the previous 6 years. By Andrea Nuñez. All can cause syndromes that are self-limited or severe. Dynamics of dengue serotype 2 virus isolated from patients with different disease severity, namely flu-like classic dengue fever (DF) and dengue shock syndrome (DSS) were studied in its mosquito vector Aedes aegypti. Although all four serotypes of dengue circulate in Sri Lanka, persons who have the severe form of the disease are most frequently infected with DENV-3 (20, 22). Patients can be infected with more than one serotype of dengue virus in their lifetime. Dengue viruses have spread rapidly within countries and across regions in the past few decades, resulting in an increased frequency of epidemics and severe dengue disease, hyperendemicity of multiple dengue virus serotypes in many tropical countries, and autochthonous transmission in Europe and the USA. Sri Lanka lies in the dengue endemic region where dengue virus (DENV) infection and numerous cases of DF and dengue haemorrhagic fever (DHF) have been reported since the 1960s [ 1, 2 ]. DHF/DSS initially presents with very similar symptoms to DF. Tissue Antigens 60 , 309 – 318 ( 2002 ). Dengue is the most rapidly spreading viral disease transmitted by the bite of infected Aedes mosquitos. Keywords: Dengue, Secondary infection, Severe dengue, Dengue type 4, Brazil A theory about dengue has been proved: Antibodies generated by a previous bout of the disease put a person at risk of more severe second infection. Results. In vitro studies have found that when DENV–TIPs and DENV coinfect a cell, they compete for viral genomes and cell proteins for replication and packaging, and DENV–TIPs outperform DENV in this process. Serotype of dengue virus has correlation with severity of dengue fever due to host immune response. Researchers test mechanisms explaining differences in dengue serotype and disease severity by statistically fitting mathematical models to viral load data from dengue … acute and self{limiting and may range from being mild to one of the severe forms, such 7 as dengue hemorrhagic fever or dengue shock syndrome, which may be life{threatening. 7,8 Dengue is mainly spread by Aedes aegypti mosquitoes and, to a lesser extent, Aedes albopictus mosquitoes. Raised liver enzymes and increased ferritin are good biomarkers in differentiating dengue from severe dengue with cutoff levels for AST (134 U/L), ALT (88 U/L), and ferritin (3670 ng/ml). The RT-LAMP assay is very simple and rapid, wherein the amplification can be obtained in … DEN-3 Dengue virus serotype 3 DEN-4 Dengue virus serotype 4 DF Dengue fever DHF Dengue haemorrhagic fever DIVC Disseminated intravascular coagulopathy ... dynamic nature, the severity of the disease will usually only be apparent around defervescence i.e. Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil Benigno A. M. Rocha , 1, 3 Adriana O. Guilarde , 1 Angela F. L. T. Argolo , 1 Marianna Peres Tassara , 1 Lucimeire A. da Silveira , 1 Isabela C. Junqueira , 1 Marília D. Turchi , 1 Valéria C. R. Féres , 2 and Celina M. T. Martelli 1 BMC Infect Dis. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, Nisalak A. J Infect Dis, (1):2-9 2000 MED: 10608744 doi: 10.1034/j.1399-0039.2002.600405.x pmid: 12472660 Serotype distribution may be predictive of future epidemiology and is important information for dynamic … IMMUNOLOGY Antibody fucosylation predicts disease severity in secondary dengue infection Stylianos Bournazos1, Hoa Thi My Vo2,Veasna Duong3, Heidi Auerswald3, Sowath Ly4, Anavaj Sakuntabhai5,6, Philippe Dussart3,Tineke Cantaert2†*, Jeffrey V. Ravetch1†* Although antiviral antibodies generally confer protective functions, antibodies against dengue virus No mortality occurred in our study. Conclusion DENV 2 is the most common serotype with maximum severity at our hospital. Dengue presents with a range of symptoms, ranging from asymptomatic through to mild infection to severe illness with life-threatening outcomes. ... especially in people who have previously been exposed to a different serotype … Takeda's tetravalent dengue vaccine candidate (TAK-003) is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four vaccine viruses. It is caused by any of four dengue virus serotypes, each of which can cause dengue fever or severe dengue. 1.1 Severity of different serotypes Dengue virus consists of four serotypes with ≥30% difference in their overall amino acid sequences [ 5 ]. Malnutrition, defined as both over- and undernutrition, is a growing problem worldwide and has long been linked to dengue disease severity by epidemiological and anecdotal observations. The data indicated a high percent of severe dengue (63%) in primary infections. That figure dropped to 73.7% for serotype … has been cited by the following article: Article. Severe cases of dengue can lead to a condition called Dengue Shock Syndrome, which can be fatal. There is a small risk of severe disease after any dengue infection, but the second infection by a different serotype to the first is thought to be associated with the highest risk of severe dengue, while the third and fourth infections are usually associated with a milder clinical course. Although most cases are asymptomatic, severe illness and death may occur. Singapore saw 1,158 dengue cases in the week ending 13 June 2020, the highest number of weekly dengue cases ever recorded since 2014. Study Design: An analytical study. Dengue hemorrhagic fever is a more severe form of a … The primary end point was symptomatic VCD of any severity caused by any dengue virus serotype. Dengue serotype 5 was recently discovered in Malaysia, but transmission appears to be limited at present. Clinical and Laboratory Presentations of Dengue Patients with Different Serotypes 54 Dengue Bulletin – Vol 24, 2000 Introduction Dengue infection isthe most important mosquito-borne viral disease known to mankind. Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity David W. Vaughn,1 Sharone Green,4 Siripen Kalayanarooj,2 Bruce L. Innis,5'a 1 … This analysis supports monitoring of the warning signs described in the 2009 WHO guidelines on dengue. Lanciotti et al. severity of dengue infection in Cuba, Thailand, and Malaysia.5,31 Many studies reviewed the shift of DENV-2 as the important serotype in fatal dengue disease, especially in children.13 ,32 33 The DENV-3 serotype has been circulating worldwide since first reported in 1953 in Southeast Asia. The researchers also found a serotype of dengue known not to exist in the region. Viral evolution sustains a dengue outbreak of enhanced severity Catherine Inizan a, Marine Miniera, Matthieu Prot b, Olivia O’Connor a, Carole Forfaitc, Sylvie Laumondc, Ingrid Maroisd, Antoine Birone, Ann-Claire Gourinate, Marie-Amélie Goujarte, Elodie Desclouxd*, Anavaj Sakuntabhaif,g, Arnaud Tarantola h, Etienne Simon-Lorière b# and Myrielle Dupont-Rouzeyrol a# However, as dengue serology is usually not available at hospital admission, the presence of dengue … during the study period had severe dengue. DENV-4 was the predominant serotype, followed by DENV-1, in a large outbreak of dengue in central Brazil. Clinical course of dengue fever. 2 - 9 View Record in Scopus Google Scholar Researchers test mechanisms explaining differences in dengue serotype and disease severity by statistically fitting mathematical models to viral load data from dengue-infected individuals. Dengue is a mosquito-borne viral disease whose incidence has increased dramatically (>30-fold) in recent years, alongside the geographical expansion of Aedes mosquitoes. Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type. In humans, 9 recovery from infection by one serotype provides lifelong immunity against that 10 It is caused by any of four dengue virus serotypes, each of which can cause dengue fever or severe dengue. , HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. Dengue is a mosquito-transmitted virus and the leading cause of arthropod-borne viral disease in the world. Dengue Hemorrhagic Fever --- U.S.-Mexico Border, 2005. 1 … Evaluation of the Traditional and Revised WHO Classifications of Dengue Disease Severity. In addition to different serotypes, different genotypes circulate as well and are associated with varying degrees of disease severity. In total, 15 patients were co-infected with more than one dengue serotype and 12 (80%) of them had severe dengue. In this study, we examined the circulating dengue virus (DENV) and measured plasma levels of inflammatory mediators. Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. Others have more severe illness (5%), and in a small proportion it is life-threatening. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). 2006. An unmatched case-control study was conducted on 123 severe cases, and 245 controls (non-severe cases) diagnosed during 2014–2016. Symptomatic dengue infection is a systemic and dynamic disease. “In 2018, the National Dengue Virus Serotype Surveillance showed that severe dengue cases were caused by a mixture of different dengue viruses, … Currently there is a co-circulation of the four dengue serotypes after DENV-4 was reintroduced in 2010 [ 6, 7, 8, 9 ]. Takeda's tetravalent dengue vaccine candidate (TAK-003) is based on a live-attenuated dengue serotype 2 virus, which provides the genetic “backbone” for all four vaccine viruses. Sanofi Pasteur has started producing its experimental dengue vaccine, the world's first, which it hope to launch in 2015. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines. A small percentage of persons who have previously been infected by one dengue serotype develop bleeding and endothelial leak upon infection with another dengue serotype. The present study found that cases of DENV-2 had a higher proportion of severe dengue than among those of DENV-1 and DENV-4. The co-circulation of multiple dengue serotypes is a population-level risk factor for severe dengue disease because of the increased likelihood of a second or subsequent infection, and also due to the fact that sequential infections are associated with increased severity . The burden of dengue, severe dengue, and mortality was noted especially in the districts of the east coast of Sabah. Determination of the infecting serotype may be important in gauging the potential severity of a dengue outbreak. There has been a dramatic increase in the number of cases and the severity of the disease in the past 30 years. In addition, testing for infecting serotype and monitoring platelet count and serum albumin, AST, and ALT concentrations during the febrile phase of illness could improve the early prediction of severe dengue. Dengue is the fastest spreading mosquito-borne viral disease and was one of the WHO’s top 10 threats to global health in 2019. Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity. We report a 4.7 fold increased risk of severe dengue in patients who had a serologically documented history of previous dengue infection, in accordance with the Antibody-Dependent Enhancement (ADE) theory stating that secondary dengue infections are usually more severe . Dengue fever (DF) is a mosquito borne infection caused by four antigenically distinct virus serotypes, namely DENV-1 to 4. It has a wide clinical spectrum that includes both severe and non-severe clinical manifestations (1). The total number of cases of non-hospitalized dengue fever (DF), hospitalized DF, and dengue hemorrhagic fever (DHF) are shown by dengue (DENV) serotype (3a). Dengue is a positive-sense RNA virus belonging to the Flaviviridae family. The development and validation of a one-step, real-time, and quantitative dengue virus serotype-specific reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay targeting the 3′ noncoding region for the rapid detection and differentiation of dengue virus serotypes are reported. Results: Of the 248 patients with laboratory-confirmed dengue and defined serological and clinical classifications 29 (11.7%) had primary DF, 150 (60.5%) had secondary DF, 4 (1.6%) had primary DHF and 65 (26.2%) had secondary DHF. PDF. Place and duration of study: Services Institute of Medical Science and Fatima Memorial Hospital, Lahore, from September to December 2010. Immune gene expression changes during progression to severe dengue … Takeda's tetravalent dengue vaccine candidate (TAK-003) is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four vaccine viruses. Objective: To assess the utility of liver function tests (LFTs) for early recognition and prediction of severity of dengue fever in hospitalized patients.

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